Sung, Hooten and Villanueva join forces to convince Trisha Miller, a 13-year-old girl with an advanced brain stem glioma, to try surgery one last time before giving up. Shaken from losing a patient, Ty turns to Dr. Tina Ridgeway for support. Meanwhile, Dr. Buck Tierney tries to bully resident Michelle Robideux into pronouncing a potential organ donor brain dead. And Sydney enlists Villanueva's help diagnosing a patient under the care of internist Dr. John Lieberman.